文章基本信息

标题：Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin
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作者：Mekdes Debela ; Viktor Magdolen ; Wolfgang Skala 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10705
DOI：10.1038/s41598-018-29058-6
语种：English
出版社：Springer Nature
摘要：, which are important in neuron and skin physiology. Both cations participate in the allosteric surface loop network present in related serine proteases. A comparison of the positional scanning data with substrates from brain suggests an adaptive recognition by KLK8, based on the tertiary structures of its targets. These combined findings provide a comprehensive picture of the molecular mechanisms underlying the enzyme activity of KLK8.