文章基本信息

标题：Inactivation of TCA cycle enhances Staphylococcus aureus persister cell formation in stationary phase
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作者：Ying Wang ; Martin Saxtorph Bojer ; Shilpa Elizabeth George 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：10849
DOI：10.1038/s41598-018-29123-0
语种：English
出版社：Springer Nature
摘要：ATPase. In S. aureus, TCA cycle activity and gene expression are de-repressed in stationary phase but single cells with low expression may be prone to form persisters. While ATP levels were not consistently affected in high persister mutants they commonly displayed reduced membrane potential, and persistence was enhanced by a protein motive force inhibitor. Our results show that persister cell formation in stationary phase does not correlate with ATP levels but is associated with low membrane potential.