文章基本信息

标题：Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites
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作者：Sarah J. Reiling ; Georg Krohne ; Oliver Friedrich 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：11137
DOI：10.1038/s41598-018-29422-6
语种：English
出版社：Springer Nature
摘要：in CQS but not CQR parasites caused the appearance of hitherto undescribed hemozoin (Hz)-containing compartments in the parasite cytosol. Hz-containing compartments were very rarely observed in CQR parasites even after CQ exposures sufficient to cause irreversible cell death. These findings challenge current concepts that CQ killing of malaria parasites is solely concentration-dependent, and instead suggest that CQS and CQR strains fundamentally differ in the consequences of CQ exposure.