文章基本信息

标题：Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners
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作者：Sylvain D. Vallet ; Adriana E. Miele ; Urszula Uciechowska-Kaczmarzyk 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：11768
DOI：10.1038/s41598-018-30190-6
语种：English
出版社：Springer Nature
摘要：: 3.7 nm). We generated 3D models of the propeptide by coarse-grained molecular dynamics simulations restrained by SAXS data, which were used for docking experiments. Furthermore, we have identified 17 new binding partners of the propeptide by label-free assays. They include four glycosaminoglycans (hyaluronan, chondroitin, dermatan and heparan sulfate), collagen I, cross-linking and proteolytic enzymes (lysyl oxidase-like 2, transglutaminase-2, matrix metalloproteinase-2), a proteoglycan (fibromodulin), one growth factor (Epidermal Growth Factor, EGF), and one membrane protein (tumor endothelial marker-8). This suggests new roles for the propeptide in EGF signaling pathway.