文章基本信息

标题：Calcium increases titin N2A binding to F-actin and regulated thin filaments
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作者：Samrat Dutta ; Christopher Tsiros ; Sai Lavanyaa Sundar 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：14575
DOI：10.1038/s41598-018-32952-8
语种：English
出版社：Springer Nature
摘要：increases the strength and stability of N2A - actin interactions, supporting the hypothesis that titin plays a regulatory role in muscle contraction. The results further support a model in which N2A - actin binding in active muscle increases titin stiffness, and that impairment of this mechanism contributes to the phenotype in muscular dystrophy with myositis. Future studies are required to determine whether titin - actin binding occurs in skeletal muscle sarcomeres in vivo.