文章基本信息

标题：Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin
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作者：Kavindra Nath ; Jeffrey Roman ; David S. Nelson 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：14654
DOI：10.1038/s41598-018-33019-4
语种：English
出版社：Springer Nature
摘要：H MRS with a selective multiquantum pulse sequence and Hadamard localization, we show that LND induced a significant increase in tumor lactate levels (p < 0.01). LND pre-treatment followed by DOX (10 mg/kg, i.v.) produced a growth delay of 13.7 days in WM983B (p < 0.01 versus control), a growth delay significantly smaller than the 25.4 days that occurred with DB-1 (p = 0.03 versus WM983B). Differences in relative levels of glycolysis may produce differential therapeutic responses of DB-1 and WM983B melanomas.