文章基本信息

标题：Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation
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作者：Eri Takenaka ; Anh Van Vo ; Yumi Yamashita-Kanemaru 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：15180
DOI：10.1038/s41598-018-33437-4
语种：English
出版社：Springer Nature
摘要：T cells priming by SPMs. Furthermore, T and B cell responses in mediastinal lymph nodes of mice intraperitoneally immunized with trinitrophenyl (TNP)-OVA protein in Alum adjuvant were enhanced by intraperitoneally transferred wild-type, but not DNAM-1-deficient, SPMs. We propose that SPMs are functionally distinct from LPMs, and DNAM-1 plays a costimulatory role in antigen presentation by SPMs.