文章基本信息

标题：An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells
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作者：Sushmita Sinha ; Nicholas Borcherding ; Pranav S. Renavikar 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：15440
DOI：10.1038/s41598-018-33901-1
语种：English
出版社：Springer Nature
摘要：CD8 T-cells were deficient in transcription factors associated with long-term functional memory formation. Our study reveals biological consequences of the SNP rs2281808 and provides novel insights into the potential mechanisms by which SIRPγ might regulate human immune responses.