文章基本信息

标题：Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism
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作者：Osamu Morinaga ; Kan’ichiro Ishiuchi ; Takeshi Ohkita 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：15568
DOI：10.1038/s41598-018-33834-9
语种：English
出版社：Springer Nature
摘要：of 1 for type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) was 2.0 µM. Similar plasma concentrations of 1 and GA were observed 12 h after oral administration of GA to EHBR. Compound 1 was eliminated via urine, whereas GA was not. In Sprague-Dawley (SD) rats orally treated with GA, compound 1 was absent from both the plasma and the urine. Compound 1 was actively transported into cells via OAT1 and OAT3, whereas GA was not. Compound 1, when produced in Mrp2-deficiency, represents a potential causative agent of pseudoaldosteronism, and might be used as a biomarker to prevent the adverse effect.