文章基本信息

标题：A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma
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作者：Duangporn Saengwimol ; Duangnate Rojanaporn ; Vijender Chaitankar 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：15664
DOI：10.1038/s41598-018-34037-y
语种：English
出版社：Springer Nature
摘要：) in organoids after 24-h drug exposure, blocking mitotic entry. In contrast, methotrexate showed the least efficacy against tumor cells. The drug responses of organoids were consistent with those of tumor cells in advanced disease. Patient-derived organoids enable the creation of a faithful model to use in examining novel therapeutics for RB.