文章基本信息

标题：Rerouting of NADPH synthetic pathways for increased protopanaxadiol production in Saccharomyces cerevisiae
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作者：Jae-Eung Kim ; In-Seung Jang ; Bong Hyun Sung 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：15820
DOI：10.1038/s41598-018-34210-3
语种：English
出版社：Springer Nature
摘要：) were utilized to construct the PPD biosynthetic pathway. Rerouting the redox metabolism to improve NADPH availability in the engineered S. cerevisiae also increased PPD production. Combining these approaches resulted in more than an 11-fold increase in PPD titer over the initially constructed strain. The series of metabolic engineering strategies of this study provides a feasible approach for the microbial production of PPD and development of microbial platforms producing other industrially-relevant terpenoids.