文章基本信息

标题：Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B
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作者：Tomohisa Hatta ; Shun-ichiro Iemura ; Tomokazu Ohishi 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：16756
DOI：10.1038/s41598-018-35204-x
语种：English
出版社：Springer Nature
摘要：mouse embryonic fibroblasts shows that MAP1B, a member of the MAP1 family of proteins, is localized at actin filaments rather than at microtubules. Furthermore, fluorescence recovery after photo-bleaching analysis shows that calpain-10 regulates actin dynamics via MAP1B cleavage. Moreover, in pancreatic islets from CAPN10 knockout mice, insulin secretion was significantly increased both at the high and low glucose levels. These findings indicate that deficiency of calpain-10 expression may affect insulin secretion by abnormal actin reorganization, coordination and dynamics through MAP1 family processing.