文章基本信息

标题：Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques
本地全文：下载
作者：Yusuke Kageyama ; Atsushi Saito ; Olga Pletnikova 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：16895
DOI：10.1038/s41598-018-35004-3
语种：English
出版社：Springer Nature
摘要：decade of the life, at the same time that 11A1 IR increased in the extracellular space. Our findings indicate that the Aβ toxic conformer is normally present in various cell types and brain parenchyma, and appears to be constitutively produced, degraded, and cleared from the inferior parietal cortex. The decrease in pericapillary Aβ and the concomitant increase of extracellular Aβ may reflect an age-associated impairment in Aβ clearance from the brain.