文章基本信息

标题：A structural-chemical explanation of fungal laccase activity
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作者：Rukmankesh Mehra ; Jan Muschiol ; Anne S. Meyer 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：17285
DOI：10.1038/s41598-018-35633-8
语种：English
出版社：Springer Nature
摘要：is not just a binding constant but also contains features of the enzymatic activity. In addition, we identify QSAR models with only a few descriptors showing that phenolic substrates employ optimal hydrophobic packing to reach the T1 site, but then require additional electronic properties to engage in the subsequent electron transfer. Our results advance our ability to model laccase activity and lend promise to future rational optimization of laccases toward phenolic substrates.