文章基本信息

标题：BK channel blocker paxilline attenuates thalidomide-caused synaptic and cognitive dysfunctions in mice
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作者：Tae-Yong Choi ; Seung-Hyun Lee ; Soo-Jeong Kim 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：17653
DOI：10.1038/s41598-018-36367-3
语种：English
出版社：Springer Nature
摘要：(BK) channel expression in the plasma membrane and BK channel activity in the hippocampus. Thalidomide also increased the paired pulse ratio of excitatory postsynaptic current (EPSC), which suggests a decreased probability of glutamate release. Furthermore, the changes in the paired pulse ratio and in BK channel activity were blocked by paxilline, a BK channel blocker. Finally, we found that thalidomide-induced cognitive dysfunctions were restored by paxilline treatment. These results suggest that thalidomide-mediated BK channel hyperfunction is responsible for the pathological mechanism of thalidomide-associated reversible memory loss.