文章基本信息

标题：Phosphorylation of nuclear Tau is modulated by distinct cellular pathways
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作者：Giorgio Ulrich ; Agnese Salvadè ; Paul Boersema 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：17702
DOI：10.1038/s41598-018-36374-4
语种：English
出版社：Springer Nature
摘要：. We also report that the DNA damaging drug Etoposide increases the translocation of Tau to the nucleus whilst reducing its phosphorylation. We propose that overt phosphorylation of Tau, a hallmark of neurodegenerative disorders defined as tauopathies, may negatively regulate the function of nuclear Tau in protecting against DNA damage.