文章基本信息

标题：The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation
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作者：Simranjit Singh ; Simon Lämmle ; Heiko Giese 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：17711
DOI：10.1038/s41598-018-36267-6
语种：English
出版社：Springer Nature
摘要：is presumably important for the protection of PP-1α active surface in the absence of a substrate. We finally give insight into the electron transport from the PP-1α catalytic core to the surface. Our data suggest that the formation of transient disulfides might be a general mechanism of proteins to escape from irreversible cysteine oxidation and to prevent their complete inactivation.