文章基本信息

标题：Induction of Human T-cell and Cytokine Responses Following Vaccination with a Novel Influenza Vaccine
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作者：David A. G. Skibinski ; Leigh Ann Jones ; Yuan O. Zhu 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：18007
DOI：10.1038/s41598-018-36703-7
语种：English
出版社：Springer Nature
摘要：T-cell responses and the induction of the cytokines IFN-γ, IL-17A, IL17F, IL-5, IL-13, IL-9, IL-10 and IL-21. Pre-existing cytokine responses influenced the profile of the cytokine response elicited by vaccination. In a subset of individuals the VLP vaccine changed pre-vaccination production of type 2 cytokines such as IL-5 and IL-13 to a post-vaccination type 1 cytokine signature characterized by IFN-γ. A transcriptional signature to vaccination was found to correlate with antibody titer, IFN-γ production by T-cells and expression of a putative RNA helicase, DDX17, on the surface of immune cells.