文章基本信息

标题：Polygenic impact of common genetic risk loci for Alzheimer’s disease on cerebral blood flow in young individuals
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作者：Hannah L. Chandler ; Richard G. Wise ; Kevin Murphy 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-8
DOI：10.1038/s41598-018-36820-3
出版社：Springer Nature
摘要：< 0.05). Our findings suggest that a larger burden of AD common genetic risk alleles is associated with attenuated cerebrovascular function, during young adulthood. These results suggest that cerebral vasculature is a mechanism by which AD risk alleles confer susceptibility.