文章基本信息

标题：Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111
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作者：Sara S. Rinne ; Charles Dahlsson Leitao ; Bogdan Mitran 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-11
DOI：10.1038/s41598-018-36827-w
出版社：Springer Nature
摘要：In-DOTAGA-complex resulted in the lowest hepatic uptake and the highest tumor-to-liver ratio. In conclusion, the choice of chelator influences the biodistribution of indium-111 labeled anti-HER3 affibody molecules. Hepatic uptake of anti-HER3 affibody molecules could be reduced by the increase of negative charge of the radiometal-chelator complex on the C-terminus without significantly influencing the tumor uptake.