文章基本信息

标题：Structural basis for chemically-induced homodimerization of a single domain antibody
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作者：Jean Lesne ; Hung-Ju Chang ; Angelique De Visch 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2019
卷号：9
期号：1
页码：1-4
DOI：10.1038/s41598-019-38752-y
出版社：Springer Nature
摘要：Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.