文章基本信息

标题：Relationship of Liver Enzymes with Viral Load of Hepatitis C in HCV Infected Patients by Data Analytics
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作者：Fahad Ahmad ; Kashaf Junaid ; Ata ul Mustafa 等
期刊名称：International Journal of Advanced Computer Science and Applications(IJACSA)
印刷版ISSN：2158-107X
电子版ISSN：2156-5570
出版年度：2018
卷号：9
期号：11
DOI：10.14569/IJACSA.2018.091170
出版社：Science and Information Society (SAI)
摘要：Correlation of liver enzyme with viral load of HCV has been previously questioned. Based on previous findings this study was aimed to appraise relationship of liver chemistry with HCV RNA titer and also to assess relationship of liver enzymes with liver morphology detected on ultrasound. And for this purpose data analytics were first time used to evaluate relationships. 155 serum samples were recruited from different hepatic centers of Lahore. Liver enzymes ALT, AST, ALP and serum bilirubin was measured by photometric method on Beckman coulter. Liver morphology was noted by ultrasound. Viral load of HCV was detected by Real time polymerase chain reaction. Relationship of liver enzymes and bilirubin with viral load and with liver morphology was observed by making UCINET graphs.Results of this study indicate that alkaline amino transferase (ALT) level, aspartate amino transferase (AST) level and alkaline phosphates (ALP) are significantly correlated with viral load of HCV RNA while biochemical test bilirubin is not. A significant relationship of liver enzymes was observed with liver morphology. Genotype 3a was the most abundant genotype of HCV in this population. Elevated levels of liver enzymes significantly depict viral load in infected patients of HCV. Findings of this study suggest another prospective study with a large population.
关键词：Hepatic; hepatitis virus; liver markers; UCINET analysis