文章基本信息

标题：Changes in Lipid Profile and Insulin Resistance in Morbidly Obese Patients Following Laparoscopic Total Gastric Vertical Plication
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作者：Atefeh Golpaie ; Mohammad Javad Hosseinzadeh-Attar ; Mostafa Hoseini 等
期刊名称：Journal of Minimally Invasive Surgical Sciences
印刷版ISSN：2251-7022
电子版ISSN：2251-7030
出版年度：2012
卷号：1
期号：1
页码：24-29
DOI：10.5812/jmiss.2596
出版社：Kowsar
摘要：Background: Obesity has emerged as one of the most serious public health concerns in the 21st century. The consequences of this chronic disorder are serious. Bariatric surgery has been shown to eliminate comorbid conditions associated with obesity. Currently it is considered to be the only successful, long-term therapy for morbidly obese subjects. Objectives: The aim of this study was to evaluate the e?ect of weight reduction following laparoscopic total gastric vertical plication on anthropometric indices, lipid pro?le and insulin resistance in morbidly obese patients. Patients and Methods: 15 severely obese patients aged 32.4 10 yr were enrolled in this prospective study. Body mass index (BMI), waist circumference, high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), triglycerides (TG), fasting glucose, fasting insulin and insulin sensitivity were measured before and 6 weeks after laparoscopic total gastric vertical plication (LTGVP). Insulin-sensitivity was estimated using the homeostasis model assessment of insulin-resistance (HOMA-IR). Results: Anthropometric indices decreased signi?cantly during the 6 week period after LTGVP. TG, LDL-c, fasting insulin, HOMA-IR and QUIKI also decreased but the changes in HDL-c, TC and fasting glucose were not signi?cant. At baseline, we found a direct correlation between weight and TC, weight and fasting glucose, waist to hip ratio and TG and a negative correlation between waist to hip ratios and HDL-c. LTGVP results in signi?cant weight loss among morbidly obese subjects, and following weight reduction, lipid pro?le and insulin resistance improved.
关键词：Obesity; Bariatric Surgery; Laparoscopy; Dyslipidemias; Insulin Resistance