文章基本信息

标题：An integrative classification model for multiple sclerosis lesion detection in multimodal MRI
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作者：Zhang, Fengqing ; Zhang, Fengqing ; Wang, Ji-Ping 等
期刊名称：Statistics and Its Interface
印刷版ISSN：1938-7989
电子版ISSN：1938-7997
出版年度：2019
卷号：12
期号：2
页码：193-202
DOI：10.4310/SII.2019.v12.n2.a1
出版社：International Press
摘要：We study a classification problem of multiple sclerosis (MS) lesions in three dimensional brain magnetic resonance (MR) images. Segmentation of MS lesions is essential for MS diagnosis, assessment of disease progression and evaluation of treatment efficacy. Accurate identification of MS lesions in MR images is challenging due to variability in lesion location, size and shape in addition to anatomical variability between subjects. We propose a supervised classification algorithm for segmenting MS lesions, which integrates the intensity information from multiple MRI modalities, the texture information, and the spatial information in a Bayesian framework. A multinomial logistic regression is employed to learn the posterior probability distributions from the intensity information, combined from three MRI modalities. Texture features are selected by the Elastic Net model. The spatial information is then incorporated using a Markov random field prior. Finally, a maximum a posteriori segmentation is obtained by the graph cuts algorithm. We illustrate the effectiveness of our proposed model for lesion segmentation using both the synthetic BrainWeb data and the clinical neuroimaging data..
关键词：supervised classification algorithm; multiple sclerosis; segmentation; multimodal MRI