文章基本信息

标题：Saffron (Crocus sativus L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies
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作者：Rebekka Heitmar ; Rebekka Heitmar ; James Brown 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：3
页码：649
DOI：10.3390/nu11030649
出版社：MDPI Publishing
摘要：Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.
关键词：saffron; Crocus Sativus L.; crocin; crocetin; supplements; anti-oxidant; anti-inflammatory; AMD; diabetes; glaucoma saffron ; Crocus Sativus L. ; crocin ; crocetin ; supplements ; anti-oxidant ; anti-inflammatory ; AMD ; diabetes ; glaucoma