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  • 标题:Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis
  • 作者:Romy R. Schmidt ; Martin Fulda ; Melanie V. Paul
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2018
  • 卷号:115
  • 期号:51
  • 页码:E12101-E12110
  • DOI:10.1073/pnas.1809429115
  • 语种:English
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining ( i ) energy-dependent changes in the composition of the acyl-CoA pool and ( ii ) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy.
  • 关键词:low-oxygen stress ; integrative signaling ; acyl-CoA ; ERFVII ; ACBP
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