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  • 标题:Clinical effects of dexmedetomidine combined with methadone after intranasal and intramuscular administration in dogs
  • 作者:Daniela Gioeni ; Federica Di Cesare ; Elisa Silvia D'urso
  • 期刊名称:International Journal of Health, Animal Science and Food Safety
  • 印刷版ISSN:2283-3927
  • 出版年度:2018
  • 卷号:5
  • 期号:1s
  • DOI:10.13130/2283-3927/10042
  • 语种:English
  • 出版社:Department of Health, Animal Science and Food Safety (VESPA)
  • 摘要:The intranasal (IN) route shows promise for chemical restraint given the large area offered for drugs absorption. The nasal turbinates increase nasal mucosa surface, which have a greater blood flow than muscle, brain and liver tissue . Aim of the study is to compare the clinical effects and sedation scores following either IN or intramuscular (IM) administration of dexmedetomidine-methadone in dogs. Twenty mixed-breed, client-owned, healthy dogs, undergoing soft tissue surgery or diagnostic procedures, were randomly allocated in two groups (n = 10) to receive dexmedetomidine (0.01 mg kg -1 ) together with methadone (0.4 mg kg -1 ) IN (IN-group) or IM (IM-group). Temperament was evaluated before premedication (1 = calm and friendly, 4 = very excitable or nervous) (Maddern et al. 2010). Heart rate (HR), respiratory frequency ( f R ) , body temperature, and side effects were recorded before (T0) and 10 (T10), 20 (T20) and 30 (T30) minutes after premedication. Sedation was scored 3 times (every 10 minutes) after drugs administration using a descriptive sedation scale (0 = no sedation, 13 = extremely sedated). Induction was performed at T30 with titrate-to-effect propofol and the dosage was recorded. Student T-test was performed. Weight, age, temperament, body temperature and propofol dose were not different between groups. At each time point, excluding T0, IM-group showed a statistically lower HR and f R compared to IN-group. No undesirable effects were observed in both groups. Sedation score in IM-group was significantly higher compared to IN-group at each time point. In conclusion, despite statistical differences, IN administration produces a satisfactory clinical sedation with more gradual hemodynamic effects compared to IM injection; this is probably due to a direct transport of drugs from cranial nerves (I-V) to brain with limited systemic absorption. However, the high variability recorded in sedation score between subjects in IN-group (min 1/13; max 13/13 at T30) probably arises from a variable drugs conveyance from nasal mucosae to target cell in CNS by IN administration.
  • 其他关键词:Intranasal; Sedation; Dexmedetomidine; Methadone; Dog
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