摘要：An alternative synthetic route toward a key intermediate in the total synthesis of isoschizogamine is described. The Claisen–Johnson rearrangement stereoselectively constructed a quaternary carbon. Trifluoroperacetic acid mediated the Baeyer–Villiger oxidation to form a bicyclic lactone. The Mukaiyama–Matsuo protocol converted the lactone into an α,β-unsaturated lactone, that was used as the substrate for the rhodium-mediated 1,4-addition of an arylboronic acid.
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