文章基本信息

标题：Effect of mother-in-law’s tongue leaves (Sansevieria trifasciata) extract’s solvent polarity on anti-diabetic activity through in vitro α-glucosidase enzyme inhibition test
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作者：Mauhibah Yumna ; Angelina ; Abdullah 等
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2018
卷号：67
页码：1-5
DOI：10.1051/e3sconf/20186703003
出版社：EDP Sciences
摘要：Diabetes Mellitus (DM) is a metabolic disease caused by elevated blood glucose levels above normal values (hyperglycemia). Natural ingredients that contain hypoglycemic substances, can become an alternative treatment of DM, i.e. mother-in-law’s tongue leaves (Sansevieria trifasciata), which is known to contain flavonoids, glycosides, alkaloid, and steroids that have anti-diabetic activity. The goal of this research is to obtain mother-in-law’s tongue leaves crude extract which has the highest anti-diabetic activity as an α-glucosidase inhibitor. The result showed that from all solvents used, which is aquadest, 70% ethanol, and 70% ethyl acetate, extracted with 70% ethanol has the highest yield value, which is 12.69%. The percentage of inhibition α-glucosidase was 90.72% at the inhibitor concentration of 4708.71. This shows that the extract with 70% ethanol has the required bioactive compound content to act as the α-glucosidase enzyme inhibitor. Based on the identification of compounds found in the sample mother-in-law's tongue leaves extract with 70% ethanol using Gas Chromatography and Mass Spectrometry (GC-MS), compounds that have anti-diabetic activity is steroids, alkaloids, terpenoids, tocopherol, and flavonoid.
其他摘要：Diabetes Mellitus (DM) is a metabolic disease caused by elevated blood glucose levels above normal values (hyperglycemia). Natural ingredients that contain hypoglycemic substances, can become an alternative treatment of DM, i.e. mother-in-law’s tongue leaves ( Sansevieria trifasciata ), which is known to contain flavonoids, glycosides, alkaloid, and steroids that have anti-diabetic activity. The goal of this research is to obtain mother-in-law’s tongue leaves crude extract which has the highest anti-diabetic activity as an α-glucosidase inhibitor. The result showed that from all solvents used, which is aquadest, 70% ethanol, and 70% ethyl acetate, extracted with 70% ethanol has the highest yield value, which is 12.69%. The percentage of inhibition α-glucosidase was 90.72% at the inhibitor concentration of 4708.71. This shows that the extract with 70% ethanol has the required bioactive compound content to act as the α-glucosidase enzyme inhibitor. Based on the identification of compounds found in the sample mother-in-law's tongue leaves extract with 70% ethanol using Gas Chromatography and Mass Spectrometry (GC-MS), compounds that have anti-diabetic activity is steroids, alkaloids, terpenoids, tocopherol, and flavonoid.