文章基本信息

标题：Could salicylates in food have contributed to the decline in cardiovascular disease mortality? A new hypothesis.
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作者：L M Ingster ; M Feinleib
期刊名称：American journal of public health
印刷版ISSN：0090-0036
出版年度：1997
卷号：87
期号：9
页码：1554-1557
出版社：American Public Health Association
摘要：OBJECTIVES: The prophylactic effect of aspirin (at 80 mg/day) for the prevention of cardiovascular disease mortality has long been recognized. This study examined whether other salicylates are present in comparable quantities in the US food supply. METHODS: To estimate the order of magnitude for salicylates in the food supply, annual production data for selected synthetic salicylates were analyzed. RESULTS: Production figures for 1960 indicate exposure to salicylates of 250 mg/day per person, or 95 mg/day per person excluding aspirin. Trend data indicate a rise in the production of salicylates over time, reaching 341 mg/day per person, or 126 mg/day per person excluding aspirin, in 1970. CONCLUSIONS: The US ingestion of salicylates with aspirinlike properties may have increased to the point that many susceptible individuals have received a beneficial effect that has contributed to the decline in cardiovascular disease mortality.