摘要:Purpose: To describe the present status and changing patterns of medical papers related tokeywords of vaccine and vaccination published in Korea over the last 50 years, and providebasic data for future studies.Materials and Methods: 185,603 papers are registered in the medical database KoreaMed,which is run by Korean Association of Medical Journal Editors. Among these papers, a searchwith the keywords vaccine or vaccination revealed a total of 1,089 articles which were publishedon vaccine and/or vaccination during the period of September 2, 1962 to April 30, 2012.Our study endeavors to analyze these 1,089 articles.Results: Only one article published with the keywords vaccine and/or vaccination was publishedin the 1960s, and the number of journals steadily increased starting from the 1970s (24 articles)to 2 times, 10 times, 20 times in the 1980s, 1990s, and the 2000s (585 articles), respectively.The articles were classified into reviews (20.2%), original articles with clinical study (40.7%),original articles with experimental study (24.6%), and case reports (8.2%). The review articlesmainly dealt with an overview. The original articles with clinical study were on epidemiology,effect and immunogenicity, clinical trial. Original articles with experimental study were mainlycomprised of complication and overview. Articles on vaccine, pathogen or disease topics weremostly microorganisms such as bacteria or viruses, and studies on anti-cancer vaccines orvaccines of specific diseases were sparse.Conclusion: The above data reflects the clinical uses of vaccines in Korea and the history ofvaccine studies. The number of vaccine-related articles is increasing rapidly since the first articlewas published in 1962. This implies that with the increase of studies of clinical trials, clinicaluses and results and analyses of the results, articles relating to basic studies are also onthe rise. We intend these findings to be of use to researchers in this active and expanding field.