摘要：Background: This study sought to determine the effect of a 12-week low-calorie diet (LCD) and behavioral modification program on fasting plasma glucose (FPG) levels, glycated hemoglobin (GHb) levels, use of hypoglycemic agents, and change in glycemic parameters in an overweight or obese population with type 2 diabetes mellitus. Methods: This was a retrospective review of 129 participants with type 2 diabetes. Logistic regression analysis was conducted to explore predictors associated with improvement in glycemic parameters. Results: FPG decreased from 7.77 ± 2.62 mmol/l at baseline to 6.66 ± 1.93 mmol/l after 12 weeks (p=0.0013). GHb decreased from 7.34 ± 1.38% at baseline to 6.55 ± 0.95% after 12 weeks (p 7.0% to achieve optimal glycemic parameters after 12 weeks (OR 4.6, 95% CI [1.4,15.7]). Conclusions: A 12-week low-calorie diet combined with a behavioral modification program is effective in reducing FPG, GHb, and use of hypoglycemic agents and it is associated with acute improvement in glycemic parameters in obese subjects with type 2 diabetes mellitus.mechanisms controlling skeletal muscle mass to that of the lean, while reducing body mass.
Loading...
