文章基本信息

标题：A novel approach to directly observed therapy for tuberculosis in an HIV-endemic area.
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作者：M Desvarieux ; P R Hyppolite ; W D Johnson Jr 等
期刊名称：American journal of public health
印刷版ISSN：0090-0036
出版年度：2001
卷号：91
期号：1
页码：138-141
语种：English
出版社：American Public Health Association
摘要：OBJECTIVES: This study evaluated a novel approach to the delivery of directly observed therapy (DOT) for tuberculosis in Haiti. METHODS: A total of 194 patients (152 HIV seropositive, 42 HIV seronegative) received daily unsupervised triple-drug therapy for 4 to 8 weeks, followed by twice-weekly 2-drug therapy for the remainder of the 6-month period. DOT was deferred until initiation of the twice-weekly phase. RESULTS: A total of 169 of 194 patients (87.1%) completed the 6-month course. The program of deferred DOT had an effectiveness of 85%. Overall cost was reduced by approximately 40%. CONCLUSIONS: Flexible approaches to DOT, integrating behavioral knowledge, cost considerations, and practicality may improve completion rates and program effectiveness.