摘要:Transgender women are at high risk for HIV, substance abuse, and mental health problems. We describe a health promotion intervention program tailored to transgender women in San Francisco. The program creates a safe space for providing transgender-sensitive education about HIV risk reduction, substance abuse prevention, and general health promotion. Transgender health educators conduct workshops and make referrals to appropriate substance abuse treatment programs and other services in the community. Evaluation findings indicate that this community-tailored intervention may be an effective way to reach transgender women and reduce sexual risk behaviors, depression, and perceived barriers to substance abuse treatment. THE TERM TRANSGENDER refers to individuals whose gender identity and gender expression contrast with their biological sex. 1 In San Francisco, the male-to-female transgender community (individual members are referred to here as transgender women) shows some of the highest rates of HIV incidence, substance use, and mental health problems among all groups at risk. 2– 4 Qualitative research indicates that ecological and psychosocial factors associated with transgender identity—such as discrimination, stigma, health service barriers, and poor social support—contribute to HIV risk and co-occurring health problems. 5, 6 Researchers have urged the public health community to address health disparities facing transgender individuals. 7– 11 Many service providers are not trained in transgender care issues and might be insensitive to the psychosocial needs of transgender clients. Transgender women have reported discrimination in health services, and often they are uncomfortable disclosing their gender history to providers. This report describes a program for transgender women in San Francisco, the Transgender Resources and Neighborhood Space (TRANS) program, designed to reduce HIV risk and substance use.