摘要：Background. Drug-resistant tuberculosis (TB) is a serious threat in industrialized countries,but information from Southern Italy is lacking. Here, we present the results of aretrospective study of TB cases diagnosed in 2008-2013 in Naples, the largest city inSouthern Italy.Methods. Six hundred ninety Mycobacterium tuberculosis strains were isolated at the Ospedalidei Colli of Naples, and resistance to first-line and second-line drugs was determined.Results. Multidrug-resistant (MDR) TB increased from 2008 to 2013, with 77.4% ofstrains isolated from migrants from 41 countries. Overall, 4.5% of strains were MDR:Italian-born persons, 2.2%; Romania, 7.5%; Former Soviet Union countries (Ukraine,Russia, Armenia, Georgia), 22.4%; all other foreign countries, 2.0%. Resistance of MDRstrains to second-line drugs was high against kanamycin, ofloxacin, capreomycin.Conclusions. MDR-TB in Naples increased in 2008-13 and was observed predominantlyin migrants, indicating the need to intensify diagnosis and treatment of these populationsin this town.
关键词：tuberculosis; Mycobacterium tuberculosis; drug resistance; migrants; Naples; Italy
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