文章基本信息

标题：Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
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作者：Alejandra Guerra-Castellano ; Antonio Díaz-Quintana ; Gonzalo Pérez-Mejías 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2018
卷号：115
期号：31
页码：7955-7960
DOI：10.1073/pnas.1806833115
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear. Here, we report the structural features and functional behavior of a phosphomimetic cytochrome c mutant, which was generated by site-specific incorporation at position 97 of p -carboxymethyl-
关键词：cytochrome c ; electron transport chain ; oxidative stress ; phosphorylation ; reactive oxygen species