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标题：بررسی رابطه سطح آنزیم گلوکز شش فسفات دهیدروژناز به روش اسپکتروفوتومتری با بیماری ویتیلیگو
其他标题：Association between Spectrophotometric Assayed of Glucose 6 Phosphate Dehydrogenase (G6PD) Enzyme and Vitiligo
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作者：Fariba Iraji ; Pegah Jafari ; Maryam Aghaei 等
期刊名称：Knowledge & Health Journal
印刷版ISSN：1735-577X
出版年度：2018
卷号：13
期号：2
页码：22-28
DOI：10.22100/jkh.v13i2.1897
语种：Persian
出版社：Shahroud University of Medical Sciences
摘要：مقدمه: ویتلیگو یک بیماری نسبتا شایع و اکتسابی و با علت نا مشخص می باشد لذا شناخت عوامل تاثیر گذار و پیشگیری از آن امری ضروری است. بنابراین هدف از این مطالعه بررسی رابطه سطح آنزیم گلوکز شش فسفات دهیدروژناز (G6PD) به روش اسپکتروفوتومتری با بیماری ویتیلیگو میباشد.مواد و روش: این مطالعه بر روی 104 فرد انجام گرفت (51 نفر گروه مبتلا به ویتیلیگو و 53 نفر گروه کنترل). پس از کسب رضایت از بیماران و ثبت اطلاعات دموگرافیک بیماران، سطح G6PD سرمی بیماران اندازه گیری و ثبت شد. آزمونهای کای اسکویر و ANOVA جهت مقایسه داده ها استفاده شد.یافته ها: مطالعه ما نشان داد که سطح G6PD در بیماران مبتلا به ویتیلیگو به صورت معناداری کمتر از افراد سالم میباشد (37/292 در مقابل 58/298 U/g Hb) (001/0> P) و از طرفی با گروه بندی بیماران به دو دسته محدود و منتشر، مشخص شد که سطح G6PD رابطه معکوس و معناداری با شدت ویتیلیگو دارد (در بیماران با ویتیلیگو محدود (409/0- =r و 006/0= P) و در بیماران با ویتیلیگو منتشر (906/0- =r و 005/0= P)) به عبارت دیگر با افزایش شدت بیماری ویتیلیگو، سطح G6PD کاهش میابد.نتیجه گیری: در بیماران مبتلا به ویتیلیگو، بررسی درمانهای موثر بر افزایش سطح G6PD و یا استفاده از درمانهایی در جهت عدم کاهش بیش از حد سطح G6PD در بیماران، ممکن است رویکرد درمانی جدیدی در این بیماری باشد.Introduction: Vitiligo is a relatively common and acquired disease with an uncertain cause. Therefore, it is essential to identify effective factors and prevent them. Therefore, the aim of this study was to determine the relationship between the levels of glucose 6-phosphate dehydrogenase (G6PD) with vitiligo disease by spectrophotometry.Materials and Method: This study was performed on 104 individuals (51 patients with vitiligo and 53 controls). After obtaining patients' satisfaction and recording the patients' demographic data, serum G6PD levels were measured and recorded. Chi-square and ANOVA tests were used to compare the data.Results: Our study showed that G6PD levels were significantly lower in patients with vitiligo than in healthy subjects (292.37 vs. 298.58 U/g Hb) (P <0.001), and by grouping patients in the terms of vitiligo type, the G6PD levels had a reverse and significant relationship with vitiligo severity (in patients with limited vitiligo (r = -0.499, P = 0.006) and in patients with generalized vitiligo (r = -0.906, P = 0.005). In other words, the level of G6PD decreases with increasing severity of vitiligo disease.Conclusion: In patients with vitiligo, an examination of effective treatments for increasing G6PD levels or the use of treatments to reduce excessive levels of G6PD in patients may be a new therapeutic approach
其他摘要：Introduction: Vitiligo is a relatively common and acquired disease with an uncertain cause. Therefore, it is essential to identify effective factors and prevent them. The aim of this study was to determine the relationship between the levels of glucose 6-phosphate dehydrogenase (G6PD) and vitiligo disease by spectrophotometry.Methods: This study was performed on 104 individuals (51 patients with vitiligo and 53 controls). After obtaining patients' satisfaction and recording the patients' demographic data, serum G6PD levels were measured and recorded. Chi-square and ANOVA tests were used to compare the data.Results: The study showed that G6PD levels were significantly lower in patients with vitiligo than in healthy subjects (292.37 vs. 298.58 U/g Hb) (P<0.001), and by grouping patients in the terms of vitiligo type, the G6PD levels had a reverse and significant relation with vitiligo severity (among patients with limited vitiligo (r=-0.499, P=0.006) and with generalized vitiligo (r=-0.906, P=0.005)). In other words, the level of G6PD decreases by increasing severity of vitiligo disease.Conclusion: Among patients with vitiligo, an examination of effective treatments for increasing G6PD levels or the use of treatments to reduce excessive levels of G6PD may be a new therapeutic approach.
关键词：ویتیلیگو، گلوکز شش فسفات دهیدروژناز (G6PD)، اسپکتروفوتومتری.
其他关键词：Vitiligo; Glucose Six Phosphate Dehydrogenase (G6PD); Spectrophotometry.