文章基本信息

标题：JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
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作者：Yoshitaro Tanaka ; Tetsuo Yasugi ; Masaharu Nagayama 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：12484
DOI：10.1038/s41598-018-30929-1
语种：English
出版社：Springer Nature
摘要：Organismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo , and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico . We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo , suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.