文章基本信息

标题：Improvement of osteogenesis by a uniform PCL coating on a magnesium screw for biodegradable applications
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作者：Yu-Kyoung Kim ; Kwang-Bok Lee ; Seo-Young Kim 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：13264
DOI：10.1038/s41598-018-31359-9
语种：English
出版社：Springer Nature
摘要：A polymer coating as polycaprolactone (PCL) is applied to improve the initial corrosion resistance of biodegradable magnesium. In addition, plasma electrolytic oxidation (PEO) is performed to increase adhesion between the polymer and the metal. However, when a complex-shaped material such as a screw is implanted in a bone, the surface coatings are locally damaged, and the protective role of the coating is not sufficiently maintained. In this study, the optimal conditions for producing a polymer coating on a screw were determined by varying the concentration of the PCL and the coating cycles, and were examined in vitro and in vivo . Among various the PCL coating conditions of 2 ∼ 6 cycles with 5 ∼ 7 wt.% concentrations, the 6 wt.% + 4 cycles group was applied uniformly to the screw thread. In the case of the non-uniform PCL layers, oxides and gases were present between the Mg and the PCL layer because internal magnesium corrosion and the layer peel off. The 6 wt.% + 4 cycles group had a high corrosion resistance due to the low wear on the thread. Denser and thicker bone formed around the PCL-coated screw in rat femur. This difference was due to the high corrosion resistance, which provided sufficient time for bone healing and promoting new bone growth.