文章基本信息

标题：Multiple effects of CD40–CD40L axis in immunity against infection and cancer
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作者：Anjuman Ara ; Khawaja Ashfaque Ahmed ; Jim Xiang 等
期刊名称：ImmunoTargets and Therapy
电子版ISSN：2253-1556
出版年度：2018
卷号：7
页码：55-61
DOI：10.2147/ITT.S163614
语种：English
出版社：Dove Medical Press Ltd
摘要：CD8⁺ cytotoxic T lymphocyte (CTL) protects against infection and cancer cells. Understanding the mechanisms involved in generation and maintenance of effective CTL responses is essential for improving disease therapy and vaccine protocols. During CTL responses, immune cells encounter several tightly regulated signaling pathways; therefore, in such a dynamic process, proper integration of critical signals is necessary to orchestrate an effective immune response. In this review, we have focused on CD40–CD40L interactions (a key signal) in the regulation of dendritic cell (DC)–T cell (CD4⁺ T and CD8⁺ T) cross-talk, rescuing CTL exhaustion, and converting DC tolerization. We have also highlighted the knowledge gap and future directions to design immunotherapies.
关键词：CD40–CD40L; costimulatory signals; T-cell immunity; CTL exhaustion; mTORC1; trogocytosis