文章基本信息

标题：Gel aloe vera reduces MMP-9 in diabetic wounds
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作者：Yunita Sari ; Iwan Purnawan ; Dhadhang Wahyu Kurniawan 等
期刊名称：E3S Web of Conferences
印刷版ISSN：2267-1242
电子版ISSN：2267-1242
出版年度：2018
卷号：47
页码：1-8
DOI：10.1051/e3sconf/20184707008
出版社：EDP Sciences
摘要：Gel aloe vera (GAV) is a good candidate for wound treatment for fisheries, since it is cheap, could be grown in coastal areas, and could reduce inflammation, infection and improve reepithelialization in diabetic wound. However, the effect of GAV on reducing matrix metalloproteinase (MMP)-9 is still unknown. High level of MMP-9 is one of the reasons why diabetic wounds frequently fail to heal. Abundant level of MMP-9 will cause degradation of collagen formation. Therefore, the purpose of this study was to investigate the effects of GAV on reducing MMP-9. The induction of diabetes was conducted by using Alloxan Monohydrate. The rats were divided into two groups, GAV group, and control group. The wound appearance, exudate, intensity of fibroblast, and intensity of MMP9 were compared. Mann-Whitney U test was used to analyze the difference in the intensity of positive cells for MMP-9. The study showed that the wound appearance in the GAV group was smaller compared with control group. In the GAV group, the intensity of positive cells for MMP-9 was significantly lower than in the control group. This study showed that GAV could reduce MMP-9, and therefore GAV could be recommended for wound treatment for patients with diabetic wound.
其他摘要：Gel aloe vera (GAV) is a good candidate for wound treatment for fisheries, since it is cheap, could be grown in coastal areas, and could reduce inflammation, infection and improve reepithelialization in diabetic wound. However, the effect of GAV on reducing matrix metalloproteinase (MMP)-9 is still unknown. High level of MMP-9 is one of the reasons why diabetic wounds frequently fail to heal. Abundant level of MMP-9 will cause degradation of collagen formation. Therefore, the purpose of this study was to investigate the effects of GAV on reducing MMP-9. The induction of diabetes was conducted by using Alloxan Monohydrate. The rats were divided into two groups, GAV group, and control group. The wound appearance, exudate, intensity of fibroblast, and intensity of MMP-9 were compared. Mann-Whitney U test was used to analyze the difference in the intensity of positive cells for MMP-9. The study showed that the wound appearance in the GAV group was smaller compared with control group. In the GAV group, the intensity of positive cells for MMP-9 was significantly lower than in the control group. This study showed that GAV could reduce MMP-9, and therefore GAV could be recommended for wound treatment for patients with diabetic wound.