文章基本信息

标题：Response-adaptive randomization using power function of hypothesis testing
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作者：Liu, Zhongqiang ; Han, Xuefeng
期刊名称：Statistics and Its Interface
印刷版ISSN：1938-7989
电子版ISSN：1938-7997
出版年度：2018
卷号：11
期号：3
页码：455-462
DOI：10.4310/SII.2018.v11.n3.a8
语种：English
出版社：International Press
摘要：Response-adaptive randomization (RAR) procedures have received extensive attention in clinical trials due to their considerations of ethics and efficiency. In the framework of RAR procedures, various target allocation proportions have been proposed and studied in literature. In this paper, we develop a family of RAR procedures using power function of corresponding hypothesis testing (RAR-P), and obtain the asymptotic properties under widely satisfied conditions. The proposed procedures are: (i) easy to understand and implement; (ii) applicable in more situations (continuous and discrete responses); (iii) more ethical than classical RAR procedures under some situations; and (iv) capable of monitoring efficiency and re-estimating sample size in clinical trials. Finally, we investigate performance of the proposed procedures through simulation studies.
关键词：power function; doubly adaptive biased coin design; allocation proportion function; efficiency and ethics