摘要：This article describes a semi-industrial method for the production of formalinized poliomyelitis vaccine developed during 1956. The general technique followed that originally devised by Salk with modifications developed locally. The vaccine was tested for safety and innocuity according to the Minimum Requirements laid down by the United States Public Health Service. Seitz filtration was found to be essential for the production of a non-infectious vaccine; filtration through glass filters proved to give inconsistent results. High initial virus titres, proper filtration methods, and the use of a sensitive tissue-culture system for safety testing were considered to be of prime importance for the production of a safe and effective vaccine. Over 60 000 infants and young children were inoculated with this vaccine in a country-wide immunization programme during the winter and spring of 1957. No untoward effects were noted; an immunological evaluation of its performance in those inoculated is in progress. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023
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