摘要：When Sarcina lutea is used as test organism in a cup-plate assay, the dose-response curves for the assay of penicillin in sera of humans and rabbits are linear with the square of the zone diameter and log concentration of penicillin and parallel to the dose-response curve for penicillin in phosphate buffer. Suitable conditions for such assays are described, using either large square assay-plates and fish-spine beads or conventional Petri dishes and cylinders. The assay using large plates and fish-spine beads is much more accurate and economical of effort and serum. An assay method suitable for inclusion in the blood-level duration test for oily injection of procaine penicillin (International Pharmacopoeia) is described. The method makes it possible for fiducial limits to be readily computed for the potencies obtained. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567
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