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标题：Studies on the P-Q phases of A/Asia/57 influenza viruses
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作者：Hideo Fukumi
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1959
卷号：20
期号：2-3
页码：421-434
语种：English
出版社：World Health Organisation
摘要：Some 300 strains of A/Asia/57 influenza virus were tested for haemagglutination-inhibition against normal human convalescent serum and showed wide variations; some, indeed, were not inhibited at all. The same strains, when tested against rooster antisera obtained by immunization with one of three strains (Adachi, K9 and Y5), again showed considerable variation in their degree of haemagglutination-inhibition. These two series of variations were fairly closely correlated. Eight strains considered representative of the range of inhibition variation were further tested against a number of human convalescent sera and against sera from persons inoculated with monovalent Adachi vaccine; the results indicated that the order of variation did not change. Neutralization tests to determine the immunizing potency of vaccines prepared from Adachi, K9 and Y5 strains showed that Adachi vaccine had far the greatest immunogenicity and that K9 was slightly more potent than Y5. Mouse adaptation of Y5 strain considerably enhanced its immunizing potency, but did not alter its reaction to human convalescent serum. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 421 422 423 424 425 426 427 428 429 430 431 432 433 434