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标题：Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis: 1. Microbiological assay of isoniazid in serum following a standard intramuscular dose
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作者：P. R. J. Gangadharam ; A. L. Bhatia ; S. Radhakrishna 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1961
卷号：25
期号：6
页码：765-777
语种：English
出版社：World Health Organisation
摘要：Since isoniazid is metabolized in man to several derivatives with little or no specific activity against the tubercle bacillus, its rate of inactivation in the body may have an important bearing on its efficacy as an antituberculosis drug. The inactivation rate, though constant in any one person, is known to vary from individual to individual and from race to race. A series of studies on the rate of inactivation of isoniazid in Indian patients with pulmonary tuberculosis has recently been undertaken at the Tuberculosis Chemotherapy Centre, Madras. The present paper describes the first of these studies, in which the concentration of isoniazid in the serum of patients admitted to a controlled comparison of four domiciliary chemotherapeutic regimens was determined by microbiological assay four-and-a-half hours after administration of a standard dose of isoniazid (3 mg/kg body-weight). Patients with serum levels of 0.58 μg/ml or more were classified as slow inactivators of isoniazid and those with levels below 0.58 μg/ml as rapid inactivators. By this definition, 195 (61%) of the 321 patients studied were found to be slow inactivators and 126 (39%) rapid inactivators. A relationship was shown between sex and the rate of inactivation, there being a significantly higher proportion of rapid inactivators among the females than among the males. The observed estimates of the error of the microbiological assay procedure are discussed and possible ways of reducing the error suggested. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.7M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 765 766 767 768 769 770 771 772 773 774 775 776 777