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标题：An international collaborative study of the assay of the potency of poliomyelitis sera
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作者：M. Weis Bentzon ; D. G. Evans ; O. Maaløe 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1962
卷号：26
期号：3
页码：341-355
语种：English
出版社：World Health Organisation
摘要：As a first step towards the standardization of poliomyelitis vaccine, the neutralizing antibody titres of ten test antipoliomyelitis sera were measured in nine laboratories in different countries in comparison with a reference preparation. A standard neutralization test was not used by all laboratories and in general those neutralizing the serum-virus mixtures at a temperature of 37°C obtained higher titres than those laboratories using lower temperatures. When the potencies of the test sera were calculated, in terms of the reference preparation, there was good agreement by all laboratories with sera of similar neutralizing capacity. The reference sera used in this study have proved useful for obtaining relative potencies for poliomyelitis sera of different neutralizing capacity and of different origin. These potencies have been shown to vary much less from one laboratory to another than did the uncorrected titres. For technical reasons, these reference preparations are not considered ideal for international standard preparations, and new sera have been prepared for this purpose. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355