摘要：Methods previously developed for determination of the TPI potency of strongly reactive sera have required modification to permit confidence in estimating potency in weakly reactive sera so as to correct for apparent blank reactivity and for possible inhibition by other serum constituents when a high enough serum concentration is used to permit detection of TPI activity. The intrinsic or blank potency (w′) and the relative sensitivity (f) in the presence of a given amount of specimen serum are estimated separately, the latter through use of an internal standard by adding a convenient definite amount of standard serum. A primary aim of this study was to find what value of potency (p) would not be exceeded, or rarely so, by reactions of sera that had previously been evaluated as ”negative” on a crude qualitative basis; it seems that p should be 1 or less for all such specimens. Those rated previously as ”positive” appear almost always to have p greater than 3. Those with p in the interval from 1 to 3 indicate a need for further tests, preferably with fresh specimens. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720
Loading...
