标题：Serological studies in cholera: 3. Serum toxin neutralization—rise in titre in response to infection with Vibrio cholerae, and the level in the “normal” population of East Pakistan*
摘要：A method has been evaluated for the titration of antibodies to Vibrio cholerae, based on the ability of sera containing such antibodies to neutralize the inflammatory effect of a factor from V. cholerae cultures on the skin of test animals. Ninefold or greater rises in toxin-neutralization titre were found in 73% of 111 bacteriologically confirmed cholera patients in an endemic area of East Pakistan, and in 2.5% of bacteriologically negative patients. This method compares well with the microtechniques developed for the titration of vibrio-agglutinating and vibriocidal antibodies to V. cholerae. The toxin-neutralization method has the advantage that no titre rise is produced in response to vaccination with the whole-cell vaccine in current use in East Pakistan. Relatively high toxin-neutralization titres were noted among children under 15 years of age without vibriocidal or agglutinating antibodies, and without a history of prior infection with V. cholerae. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (990K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 287 288 289 290 291 292 293 294 295
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