文章基本信息

标题：A second international co-operative investigation into thioacetazone side-effects: 1. The influence of a vitamin and antihistamine supplement
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作者：A. B. Miller ; A. J. Nunn ; D. K. Robinson 等
期刊名称：Bulletin of the World Health Organization
印刷版ISSN：0042-9686
出版年度：1970
卷号：43
期号：1
页码：107-125
语种：English
出版社：World Health Organisation
摘要：As part of a large-scale international, co-operative investigation into the side-effects produced by thioacetazone employed in the treatment of tuberculosis, an evaluation has been made of a supplement incorporating vitamins and an antihistamine as a prophylactic. Over a 12-week period of treatment, the additive supplement failed to reduce the over-all frequency of side-effects or the frequency of side-effects leading to a major departure from prescribed treatment. There was also no evidence that the more serious side-effects, particularly rashes, jaundice and agranulocytosis, were reduced by the additives, although the occurrence of vomiting, which was however infrequent, was reduced. In view of this lack of appreciable benefit, as well as the higher cost and impaired keeping properties of tablets containing thioacetazone plus isoniazid when the supplement is added, the use of the supplement as a prophylactic cannot be recommended. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References . 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125